Although applications can be opened in a variety of ways, the Run line often provides the quickest route. Desktop shortcut icons are also a quick route but you have to know how to create a shortcut for all the applications and you may end up with dozens of icons.
The best candidates for the Run line are applications that are in the "path" environment.The path environment is a set of folders whose names do not have to be included when entering a command. The path environment variable normally includes \Windows\ and \Windows\system32\. Many common accessories and Windows applets are in these folders and can be opened by entering just the executable file name. Several that I use constantly are the Registry editor (regedit) and the System Configuration Utility (msconfig). Note that neither of these frequently used system tools has an entry in Start- All Programs. The Run line is the standard method of accessing them.